Characterization of the osmotic response element of the human aldose reductase gene promoter.
Aldose reductase (EC 1.1.1.21) catalyzes the NADPH-mediated conversion of glucose to sorbitol. The hyperglycemia of diabetes increases sorbitol production primarily through substrate availability and is thought to contribute to the pathogenesis of many diabetic complications. Increased sorbitol prod...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1996
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8624 |
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