Characterization of the osmotic response element of the human aldose reductase gene promoter.
Aldose reductase (EC 1.1.1.21) catalyzes the NADPH-mediated conversion of glucose to sorbitol. The hyperglycemia of diabetes increases sorbitol production primarily through substrate availability and is thought to contribute to the pathogenesis of many diabetic complications. Increased sorbitol prod...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1996
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8624 |
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