Eradication of large colon tumor xenografts by targeted delivery of maytansinoids.

The maytansinoid drug DM1 is 100- to 1000-fold more cytotoxic than anticancer drugs that are currently in clinical use. The immunoconjugate C242-DM1 was prepared by conjugating DM1 to the monoclonal antibody C242, which recognizes a mucin-type glycoprotein expressed to various extents by human color...

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Autores principales: Liu, C, Tadayoni, B M, Bourret, L A, Mattocks, K M, Derr, S M, Widdison, W C, Kedersha, N L, Ariniello, P D, Goldmacher, V S, Lambert, J M, Blättler, W A, Chari, R V
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC38722/
https://ncbi.nlm.nih.gov/pubmed/8710920
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