Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes

Thrombin is a key mediator of fibrin deposition, angiogenesis, and proinflammatory processes. Abnormalities in these processes are primary features of rheumatoid arthritis and osteoarthritis. Matrix metalloproteinase-13 (MMP-13) may contribute to the breakdown of articular cartilage during arthritis...

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Autori principali: Huang, Chun-Yin, Lin, Hsiu-Jung, Chen, Hsin-Shui, Cheng, Shi-Yann, Hsu, Horng-Chaung, Tang, Chih-Hsin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872103/
https://ncbi.nlm.nih.gov/pubmed/24385683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/326041
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