The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) may progress from simple steatosis to severe, nonalcoholic steatohepatitis (NASH) in 7%–14% of the U.S. population through a second “hit” in the form of increased oxidative stress and inflammation. Endoplasmic reticulum (ER) stress signaling and the unfolded...

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Autors principals: Lake, April D., Novak, Petr, Hardwick, Rhiannon N., Flores-Keown, Brieanna, Zhao, Fei, Klimecki, Walter T., Cherrington, Nathan J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871931/
https://ncbi.nlm.nih.gov/pubmed/24097666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft230
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