The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) may progress from simple steatosis to severe, nonalcoholic steatohepatitis (NASH) in 7%–14% of the U.S. population through a second “hit” in the form of increased oxidative stress and inflammation. Endoplasmic reticulum (ER) stress signaling and the unfolded...

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Main Authors: Lake, April D., Novak, Petr, Hardwick, Rhiannon N., Flores-Keown, Brieanna, Zhao, Fei, Klimecki, Walter T., Cherrington, Nathan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871931/
https://ncbi.nlm.nih.gov/pubmed/24097666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft230
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