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Insulin-secreting non-islet cells are resistant to autoimmune destruction.

Transgenic nonobese diabetic mice were created in which insulin expression was targeted to proopiomelanocortin-expressing pituitary cells. Proopiomelanocortin-expressing intermediate lobe pituitary cells efficiently secrete fully processed, mature insulin via a regulated secretory pathway, similar t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lipes, M A, Cooper, E M, Skelly, R, Rhodes, C J, Boschetti, E, Weir, G C, Davalli, A M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38718/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710916/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8595
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