Insulin-secreting non-islet cells are resistant to autoimmune destruction.

Transgenic nonobese diabetic mice were created in which insulin expression was targeted to proopiomelanocortin-expressing pituitary cells. Proopiomelanocortin-expressing intermediate lobe pituitary cells efficiently secrete fully processed, mature insulin via a regulated secretory pathway, similar t...

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Hlavní autoři: Lipes, M A, Cooper, E M, Skelly, R, Rhodes, C J, Boschetti, E, Weir, G C, Davalli, A M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC38718/
https://ncbi.nlm.nih.gov/pubmed/8710916
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