Hodgkin-Reed-Sternberg Cells in Classical Hodgkin Lymphoma Show Alterations of Genes Encoding the NADPH Oxidase Complex and Impaired Reactive Oxygen Species Synthesis Capacity

The membrane bound NADPH oxidase involved in the synthesis of reactive oxygen species (ROS) is a multi-protein enzyme encoded by CYBA, CYBB, NCF1, NCF2 and NCF4 genes. Growing evidence suggests a role of ROS in the modulation of signaling pathways of non-phagocytic cells, including differentiation a...

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Detalhes bibliográficos
Main Authors: Giefing, Maciej, Winoto-Morbach, Supandi, Sosna, Justyna, Döring, Claudia, Klapper, Wolfram, Küppers, Ralf, Böttcher, Sebastian, Adam, Dieter, Siebert, Reiner, Schütze, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871653/
https://ncbi.nlm.nih.gov/pubmed/24376854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084928
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