Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages

Oxidation of low-density lipoprotein (LDL) is one of the major causative mechanisms in the development of atherosclerosis. In previous studies, we showed that minimally oxidized LDL (mmLDL) induced inflammatory responses in macrophages, macropinocytosis and intracellular lipid accumulation and that...

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Main Authors: Choi, Soo-Ho, Yin, Huiyong, Ravandi, Amir, Armando, Aaron, Dumlao, Darren, Kim, Jungsu, Almazan, Felicidad, Taylor, Angela M., McNamara, Coleen A., Tsimikas, Sotirios, Dennis, Edward A., Witztum, Joseph L., Miller, Yury I.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871536/
https://ncbi.nlm.nih.gov/pubmed/24376657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083145
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