Enhanced Human Immunodeficiency Virus Type 1 Expression and Neuropathogenesis in Knockout Mice Lacking Type I Interferon Responses

The roles of Type I interferon (IFN) in human immunodeficiency virus Type 1 (HIV-1) neuropathogenesis are poorly understood; both protective and deleterious effects of IFN signaling have been described. We used genetically modified mice deficient in the Type I IFN receptor (IFNRKO) to analyze the pr...

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Detalhes bibliográficos
Main Authors: He, Hongxia, Sharer, Leroy R., Chao, Wei, Gu, Chao-Jiang, Borjabad, Alejandra, Hadas, Eran, Kelschenbach, Jennifer, Ichiyama, Koji, Do, Meilan, Potash, Mary Jane, Volsky, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association of Neuropathologists 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871403/
https://ncbi.nlm.nih.gov/pubmed/24335529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0000000000000026
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