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The Role of the Dysfunctional Akt-Related Pathway in Cancer: Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug Development
Akt serine/threonine kinases, or PKB, are key players in the regulation of a wide variety of cellular activities, such as growth, proliferation, protection from apoptotic injuries, control of DNA damage responses and genome stability, metabolism, migration, and angiogenesis. The Akt-related pathway...
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
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Hindawi Publishing Corporation
2013
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Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870877/ https://ncbi.nlm.nih.gov/pubmed/24381788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/317186 |
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