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Apo B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling: Moon: Regulation of apoB secretion by TG and insulin
OBJECTIVE: States of insulin resistance, hyperinsulinemia, and hepatic steatosis are associated with increased secretion of triglycerides (TG) and apolipoprotein B (apoB), even though insulin targets apoB for degradation. We used hepatic-specific (h) Pten knockout (ko) mice, with increased hepatic i...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870321/ https://ncbi.nlm.nih.gov/pubmed/22155452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.241356 |
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