Mibefradil reduces blood glucose concentration in db/db mice

OBJECTIVE: Numerous recent studies suggest that abnormal intracellular calcium concentration ([Ca(2+)](i)) is a common defect in diabetic animal models and patients. Abnormal calcium handling is an important mechanism in the defective pancreatic β-cell function in type 2 diabetes. T-type Ca(2+) chan...

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Hlavní autoři: Lu, Yujie, Long, Min, Zhou, Shiwen, Xu, Zihui, Hu, Fuquan, Li, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2014
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870312/
https://ncbi.nlm.nih.gov/pubmed/24473561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6061/clinics/2014(01)09
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