Drug Screening Using a Library of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Disease Specific Patterns of Cardiotoxicity

BACKGROUND: Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of adverse cardiac drug reactions are more common in patients with pre-existing heart disease than the general population. Here we gen...

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Main Authors: Liang, Ping, Lan, Feng, Lee, Andrew S., Gong, Tingyu, Sanchez-Freire, Veronica, Wang, Yongming, Diecke, Sebastian, Sallam, Karim, Knowles, Joshua W., Wang, Paul J., Nguyen, Patricia K., Bers, Donald M., Robbins, Robert C., Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870148/
https://ncbi.nlm.nih.gov/pubmed/23519760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.001883
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