Screening Adverse Drug-Induced Arrhythmia Events Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

BACKGROUND: Drug-induced arrhythmia is the most common cause of drug development failure and withdrawal from market. This study tested whether human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) combined with a low-impedance microelectrode array (MEA) system could improve upon ind...

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Detalhes bibliográficos
Main Authors: Navarrete, Enrique G., Liang, Ping, Lan, Feng, Sanchez-Freire, Verónica, Simmons, Chelsey, Gong, Tingyu, Sharma, Arun, Burridge, Paul W., Patlolla, Bhagat, Lee, Andrew S, Wu, Haodi, Beygui, Ramin E., Wu, Sean M., Robbins, Robert C., Bers, Donald M., Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855862/
https://ncbi.nlm.nih.gov/pubmed/24030418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.000570
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