Allele-specific siRNA silencing for the common Keratin 12 founder mutation in Meesmann epithelial corneal dystrophy

PURPOSE: To identify an allele-specific siRNA, against the common KRT12 mutation Arg135Thr in Meesmann epithelial corneal dystrophy (MECD) as a personalized approach to treatment. METHODS: siRNAs against the K12 Arg135Thr mutation were evaluated using a dual luciferase reporter gene assay and the mo...

Full description

Saved in:
Bibliographic Details
Main Authors: Allen, Edwin H. A., Atkinson, Sarah D., Liao, Haihui, Moore, Jonathan E., Pedrioli, Deena M. Leslie, Smith, Frances J. D., McLean, W. H. Irwin, Moore, C. B. Tara
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869971/
https://ncbi.nlm.nih.gov/pubmed/23233254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10528
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items