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Molecular pathogenesis of AML: Translating insights to the clinic

Specific combinations of mutations, including FLT3 and IDH1/IDH2/TET2, frequently co-occur in acute myeloid leukemia (AML) and are associated with poor prognosis. These mutation combinations can be modeled in mice to provide a more genetically accurate model of AML. Within these models, stem cells m...

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Bibliographic Details
Main Author: Levine, Ross L.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869618/
https://ncbi.nlm.nih.gov/pubmed/24309525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.beha.2013.10.003
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