Evidence for dysregulation of genome-wide recombination in oocytes with nondisjoined chromosomes 21

In oocytes with nondisjoined chromosomes 21 due to a meiosis I (MI) error, recombination is significantly reduced along chromosome 21; several lines of evidence indicate that this contributes to the nondisjunction event. A pilot study found evidence that these oocytes also have reduced recombination...

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Main Authors: Middlebrooks, Candace D., Mukhopadhyay, Nandita, Tinker, Stuart W., Allen, Emily Graves, Bean, Lora J. H., Begum, Ferdouse, Chowdhury, Reshmi, Cheung, Vivian, Doheny, Kimberly, Adams, Marcia, Feingold, Eleanor, Sherman, Stephanie L.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869361/
https://ncbi.nlm.nih.gov/pubmed/24014426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt433
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