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Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies.

The role of immunoglobulin structural genes in the generation of autoantibodies in humans has not been elucidated. Human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors, RFs) from unrelated people often share idiotypic antigens. Antibodies against synthetic peptides have localized two of...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Chen, P P, Albrandt, K, Orida, N K, Radoux, V, Chen, E Y, Schrantz, R, Liu, F T, Carson, D A
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1986
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386919/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3095834/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.21.8318
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