PKPD Modeling of Predictors for Adverse Effects and Overall Survival in Sunitinib-Treated Patients With GIST

A modeling framework relating exposure, biomarkers (vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor (sVEGFR)-2, -3, soluble stem cell factor receptor (sKIT)), and tumor growth to overall survival (OS) was extended to include adverse effects (myelosuppre...

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Autors principals: Hansson, E K, Ma, G, Amantea, M A, French, J, Milligan, P A, Friberg, L E, Karlsson, M O
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868978/
https://ncbi.nlm.nih.gov/pubmed/24304978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.62
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