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Regulation of Intestinal Cytochrome P450 Expression by Hepatic Cytochrome P450: Possible Involvement of Fibroblast Growth Factor 15 and Impact on Systemic Drug Exposure

Tissue-specific deletion of the gene for NADPH-cytochrome P450 (P450) reductase (CPR), the essential electron donor to all microsomal P450 enzymes, in either liver or intestine, leads to upregulation of many P450 genes in the tissue with the Cpr deletion. Here, by studying the liver-specific Cpr-nul...

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Detalhes bibliográficos
Main Authors: Zhu, Yi, Ding, Xinxin, Fang, Cheng, Zhang, Qing-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868902/
https://ncbi.nlm.nih.gov/pubmed/24184963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.088914
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