Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling

Tumor-derived exosomes have been shown to induce various immunomodulatory effects. However, the underlying signaling pathways are poorly understood. Here, we analyzed the effects of ex vivo-derived exosomes on monocytic cell differentiation/activation using THP-1 cells as model. We isolated exosomes...

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Detalhes bibliográficos
Main Authors: Bretz, Niko P., Ridinger, Johannes, Rupp, Anne-Kathleen, Rimbach, Katharina, Keller, Sascha, Rupp, Christian, Marmé, Frederik, Umansky, Ludmila, Umansky, Viktor, Eigenbrod, Tatjana, Sammar, Marei, Altevogt, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868779/
https://ncbi.nlm.nih.gov/pubmed/24225954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512806
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