Stepwise Engineering of Heterodimeric Single Domain Camelid V(H)H Antibodies That Passively Protect Mice from Ricin Toxin

In an effort to engineer countermeasures for the category B toxin ricin, we produced and characterized a collection of epitopic tagged, heavy chain-only antibody V(H) domains (V(H)Hs) specific for the ricin enzymatic (RTA) and binding (RTB) subunits. Among the 20 unique ricin-specific V(H)Hs we iden...

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Hlavní autoři: Vance, David J., Tremblay, Jacqueline M., Mantis, Nicholas J., Shoemaker, Charles B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868766/
https://ncbi.nlm.nih.gov/pubmed/24202178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519207
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