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Stepwise Engineering of Heterodimeric Single Domain Camelid V(H)H Antibodies That Passively Protect Mice from Ricin Toxin
In an effort to engineer countermeasures for the category B toxin ricin, we produced and characterized a collection of epitopic tagged, heavy chain-only antibody V(H) domains (V(H)Hs) specific for the ricin enzymatic (RTA) and binding (RTB) subunits. Among the 20 unique ricin-specific V(H)Hs we iden...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868766/ https://ncbi.nlm.nih.gov/pubmed/24202178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519207 |
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