Selective Recapitulation of Conserved and Nonconserved Regions of Putative NOXA1 Protein Activation Domain Confers Isoform-specific Inhibition of Nox1 Oxidase and Attenuation of Endothelial Cell Migration

Excessive vascular and colon epithelial reactive oxygen species production by NADPH oxidase isoform 1 (Nox1) has been implicated in a number of disease states, including hypertension, atherosclerosis, and neoplasia. A peptide that mimics a putative activation domain of the Nox1 activator subunit NOX...

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Detalhes bibliográficos
Main Authors: Ranayhossaini, Daniel J., Rodriguez, Andres I., Sahoo, Sanghamitra, Chen, Beibei B., Mallampalli, Rama K., Kelley, Eric E., Csanyi, Gabor, Gladwin, Mark T., Romero, Guillermo, Pagano, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868757/
https://ncbi.nlm.nih.gov/pubmed/24187133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521344
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