Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

Human liver cytochrome P-450NF is the form of cytochrome P-450 responsible for the oxidation of the calcium-channel blocker nifedipine, which has been reported to show polymorphism in clinical studies. By screening a bacteriophage lambda gt11 expression cDNA library, we isolated two clones: NF95 wit...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Beaune, P H, Umbenhauer, D R, Bork, R W, Lloyd, R S, Guengerich, F P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386867/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3464943/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.21.8064
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