Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

Human liver cytochrome P-450NF is the form of cytochrome P-450 responsible for the oxidation of the calcium-channel blocker nifedipine, which has been reported to show polymorphism in clinical studies. By screening a bacteriophage lambda gt11 expression cDNA library, we isolated two clones: NF95 wit...

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Main Authors: Beaune, P H, Umbenhauer, D R, Bork, R W, Lloyd, R S, Guengerich, F P
Format: Artigo
Jezik:Inglês
Izdano: 1986
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC386867/
https://ncbi.nlm.nih.gov/pubmed/3464943
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