Carboxyl-Ester Lipase Maturity-Onset Diabetes of the Young Is Associated With Development of Pancreatic Cysts and Upregulated MAPK Signaling in Secretin-Stimulated Duodenal Fluid

Carboxyl-ester lipase (CEL) maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes and pancreatic exocrine dysfunction due to mutations in the CEL gene encoding CEL. The pathogenic mechanism for diabetes development is unknown. Since CEL is expressed mainly in pancreatic acinar...

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Hlavní autoři: Ræder, Helge, McAllister, Fiona E., Tjora, Erling, Bhatt, Shweta, Haldorsen, Ingfrid, Hu, Jiang, Willems, Stefan M., Vesterhus, Mette, El Ouaamari, Abdelfattah, Liu, Manway, Ræder, Maria B., Immervoll, Heike, Hoem, Dag, Dimcevski, Georg, Njølstad, Pål R., Molven, Anders, Gygi, Steven P., Kulkarni, Rohit N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2014
Témata:
Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868055/
https://ncbi.nlm.nih.gov/pubmed/24062244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1012
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