Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young)

BACKGROUND: CEL-MODY is a monogenic form of diabetes with exocrine pancreatic insufficiency caused by mutations in CARBOXYL-ESTER LIPASE (CEL). The pathogenic processes underlying CEL-MODY are poorly understood, and the global knockout mouse model of the CEL gene (CELKO) did not recapitulate the dis...

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Main Authors: Ræder, Helge, Vesterhus, Mette, El Ouaamari, Abdelfattah, Paulo, Joao A., McAllister, Fiona E., Liew, Chong Wee, Hu, Jiang, Kawamori, Dan, Molven, Anders, Gygi, Steven P., Njølstad, Pål R., Kahn, C. Ronald, Kulkarni, Rohit N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615023/
https://ncbi.nlm.nih.gov/pubmed/23565203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060229
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