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Tethering of ICAM on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization
α(L)β(2) integrin (LFA-1) has an important role in the formation of T cell and NK cell cytotoxic immunological synapses and in target cell killing. Binding of LFA-1 to ICAM on target cells promotes not only adhesion, but also polarization of cytolytic granules in NK cells. Here we tested whether LFA...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3867939/ https://ncbi.nlm.nih.gov/pubmed/20675589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000761 |
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