Triple Combination of siRNAs Targeting TGFβ1, TGFβR2, and CTGF Enhances Reduction of Collagen I and Smooth Muscle Actin in Corneal Fibroblasts

PURPOSE. Transforming growth factor β1 (TGFβ1), TGFβ receptor (TGFβR2), and connective tissue growth factor (CTGF) are key regulators of fibrosis in the cornea and in other tissues, including liver, skin, and kidney. We developed an antifibrotic treatment targeting these three critical scarring gene...

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Hauptverfasser: Sriram, Sriniwas, Robinson, Paulette, Pi, Liya, Lewin, Alfred S., Schultz, Gregory
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867185/
https://ncbi.nlm.nih.gov/pubmed/24282226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12758
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