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Sterol-Dependent Nuclear Import of ORP1S Promotes LXR Regulated Trans-Activation of APOE
Oxysterol binding protein related protein 1S (ORP1S) is a member of a family of sterol transport proteins. Here we present evidence that ORP1S translocates from the cytoplasm to the nucleus in response to sterol binding. The sterols that best promote nuclear import of ORP1S also activate the liver X...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3867128/ https://ncbi.nlm.nih.gov/pubmed/22728266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2012.06.012 |
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