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Derivatives of dibenzothiophene for PET imaging of α7-Nicotinic Acetylcholine Receptors

A new series of derivatives of 3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)dibenzo[b,d]thiophene 5,5-dioxide with high binding affinities and selectivity for α7-nicotinic acetylcholine receptors (α7-nAChRs) (K(i) = 0.4 – 20 nM) has been synthesized for PET imaging of α7-nAChRs. Two radiolabeled members of...

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Detalhes bibliográficos
Main Authors: Gao, Yongjun, Kellar, Kenneth J., Yasuda, Robert P., Tran, Thao, Xiao, Yingxian, Dannals, Robert F., Horti, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866913/
https://ncbi.nlm.nih.gov/pubmed/24050653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401184f
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