Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.

Normal human melanocytes and five human melanoma cell lines were analyzed for production of platelet-derived growth factor (PDGF)-like activity. Three of the melanoma cell lines released an activity that inhibited binding of 125I-labeled PDGF to human foreskin fibroblasts and stimulated [3H]thymidin...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Westermark, B, Johnsson, A, Paulsson, Y, Betsholtz, C, Heldin, C H, Herlyn, M, Rodeck, U, Koprowski, H
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1986
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386682/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3020539/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.19.7197
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