Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-α

Functional microRNAs (miRNAs) are produced from both arms of their precursors (pre-miRNAs). Their abundances vary in context-dependent fashion spatiotemporarily and there is mounting evidence of regulatory interplay between them. Here, we introduce chemically synthesized pre-miRNAs (syn-pre-miRNAs)...

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Hauptverfasser: Guennewig, Boris, Roos, Martina, Dogar, Afzal M., Gebert, Luca F.R., Zagalak, Julian A., Vongrad, Valentina, Metzner, Karin J., Hall, Jonathan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866645/
https://ncbi.nlm.nih.gov/pubmed/24249224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.038968.113
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