High rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain gene.
The "silent" allele at the immunoglobulin heavy-chain locus in the pre-B-lymphocyte line 18-81 contains a correctly assembled gene. However, an amber termination codon within the variable-region gene segment prematurely terminates translation into complete heavy chain. Revertants that do produce hea...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1986
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386628/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3092221/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.18.6950 |
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