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Rapid, Stable, Chemoselective Labeling of Thiols with Julia- Kocieński Like Reagents: A Serum-Stable Alternative to Maleimide-Based Protein Conjugation()

[Image: see text] Cysteine-maleimide chemistry is widely used for peptide and protein modification. However, the formed succinimide linkage is readily hydrolyzed and is susceptible to an exchange reaction in vivo. We demonstrate that methylsulfonyl phenyloxadiazole compounds react specifically with...

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Autori principali: Toda, Narihiro, Asano, Shigehiro, Barbas, Carlos F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865870/
https://ncbi.nlm.nih.gov/pubmed/24123851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201306241
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