MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

Whether B cells serve as antigen-presenting cells (APCs) for activation of pathogenic T cells in the multiple sclerosis model experimental autoimmune encephalomyelitis (EAE) is unclear. To evaluate their role as APCs, we engineered mice selectively deficient in MHC II on B cells (B–MHC II(−/−)), and...

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Autores principales: Molnarfi, Nicolas, Schulze-Topphoff, Ulf, Weber, Martin S., Patarroyo, Juan C., Prod’homme, Thomas, Varrin-Doyer, Michel, Shetty, Aparna, Linington, Christopher, Slavin, Anthony J., Hidalgo, Juan, Jenne, Dieter E., Wekerle, Hartmut, Sobel, Raymond A., Bernard, Claude C.A., Shlomchik, Mark J., Zamvil, Scott S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865476/
https://ncbi.nlm.nih.gov/pubmed/24323356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130699
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