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The Repertoires of Peptides Presented by MHC-II in the Thymus and in Peripheral Tissue: A Clue for Autoimmunity?

T-cell tolerance to self-antigens is established in the thymus through the recognition by developing thymocytes of self-peptide-MHC complexes and induced and maintained in the periphery. Efficient negative selection of auto-reactive T cells in the thymus is dependent on the in situ expression of bot...

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Main Authors: Collado, Javier A., Guitart, Carolina, Ciudad, M. Teresa, Alvarez, Iñaki, Jaraquemada, Dolores
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865459/
https://ncbi.nlm.nih.gov/pubmed/24381570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00442
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