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Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis
The mitosis-specific phosphorylation of Histone H3 at Thr3 (H3T3ph) plays an important role in chromosome segregation by recruiting Aurora B. H3T3 phosphorylation is catalyzed by Haspin, an atypical protein kinase, whose kinase domain is intrinsically active without phosphorylation at the activation...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3865225/ https://ncbi.nlm.nih.gov/pubmed/24184212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.002 |
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