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Structural mechanism of ligand activation in human GABA(B) receptor
Human GABA(B) receptor is a G-protein coupled receptor central to inhibitory neurotransmission in the brain. It functions as an obligatory heterodimer of GBR1 and GBR2 subunits. Here we present the first crystal structures of a heterodimeric complex between the extracellular domains of GBR1 and GBR2...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3865065/ https://ncbi.nlm.nih.gov/pubmed/24305054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12725 |
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