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Lapatinib induces p27(Kip1)-dependent G₁ arrest through both transcriptional and post-translational mechanisms
Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, has been shown to have potent antitumor effects against human breast cancer. Recent studies have shown that lapatinib upregulates p27(Kip1) (here after referred to as p27) expression and induces G(1) cell cycle arrest in various types of cancer...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Landes Bioscience
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3865056/ https://ncbi.nlm.nih.gov/pubmed/23907131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25728 |
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