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Targeting mitotic exit with hyperthermia or APC/C inhibition to increase paclitaxel efficacy
Microtubule-poisoning drugs, such as Paclitaxel (or Taxol, PTX), are powerful and commonly used anti-neoplastic agents for the treatment of several malignancies. PTX triggers cell death, mainly through a mitotic arrest following the activation of the spindle assembly checkpoint (SAC). Cells treated...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3865049/ https://ncbi.nlm.nih.gov/pubmed/23907120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25591 |
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