Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI.

Mucopolysaccharidosis VI (MPS VI) is a lysosomal storage disease with autosomal recessive inheritance caused by a deficiency of the enzyme arylsulfatase B (ASB), which is involved in degradation of dermatan sulfate and chondroitin 4-sulfate. A MPS VI mouse model was generated by targeted disruption...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Evers, M, Saftig, P, Schmidt, P, Hafner, A, McLoghlin, D B, Schmahl, W, Hess, B, von Figura, K, Peters, C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710849/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8214
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