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Cyclophosphamide Induces an Early Wave of Acrolein-Independent Apoptosis in the Urothelium

PURPOSE: Hemorrhagic cystitis (HC or bladder inflammation) affects a significant number of patients undergoing cyclophosphamide (CP) chemotherapy despite treatment with 2-mercaptoethane sulfonate (Mesna) to inactivate the metabolite acrolein. While the mechanism is unknown, there is clearly acrolein...

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Detalhes bibliográficos
Main Authors: Hughes, Francis M., Corn, Alexa G., Nimmich, Andrew R., Pratt-Thomas, Jeffery D., Purves, J Todd
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864667/
https://ncbi.nlm.nih.gov/pubmed/24353901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/abb.2013.48A2002
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