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Dual Inhibition of PI3K and mTOR Signaling Pathways Decreases Human Pancreatic Neuroendocrine Tumor (PNET) Metastatic Progression

OBJECTIVES: Patients with advanced pancreatic neuroendocrine tumors (PNET) have limited therapeutic options. RAD001, an inhibitor of the mammalian target of rapamycin (mTOR) pathway, has been shown to increase progression-free survival, but not overall survival, indicating a need to identify additio...

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Detalhes bibliográficos
Main Authors: Djukom, Clarisse, Porro, Laura J., Mrazek, Amy, Townsend, Courtney M., Hellmich, Mark R., Chao, Celia
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864633/
https://ncbi.nlm.nih.gov/pubmed/24263107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0b013e3182a44ab4
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