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Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate β2-microglobulin amyloid assembly
The human protein β2-microglobulin (β2m) aggregates as amyloid fibrils in patients undergoing long-term hemodialysis. Isomerization of Pro32 from its native cis to a nonnative trans conformation is thought to trigger β2m misfolding and subsequent amyloid assembly. To examine this hypothesis, we syst...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3864314/ https://ncbi.nlm.nih.gov/pubmed/24262149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310414110 |
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