Ex Vivo Expanded Human Regulatory T Cells Can Prolong Survival of a Human Islet Allograft in a Humanized Mouse Model

BACKGROUND: Human regulatory T cells (Treg) offer an attractive adjunctive therapy to reduce current reliance on lifelong, nonspecific immunosuppression after transplantation. Here, we evaluated the ability of ex vivo expanded human Treg to prevent the rejection of islets of Langerhans in a humanize...

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Bibliographic Details
Main Authors: Wu, Douglas C., Hester, Joanna, Nadig, Satish N., Zhang, Wei, Trzonkowski, Piotr, Gray, Derek, Hughes, Stephen, Johnson, Paul, Wood, Kathryn J.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2013
Subjects:
Basic and Experimental Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864182/
https://ncbi.nlm.nih.gov/pubmed/23917725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e31829fa271
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