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Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone.

A cDNA clone for the rat glucocorticoid receptor (GR) was used to study mechanisms of GR mRNA regulation. Treatment of rat hepatoma culture cells with 0.5 microM dexamethasone caused a small, initial increase in the GR mRNA level after 6 hr as well as a 50% to 95% reduction of the GR mRNA level afte...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Okret, S, Poellinger, L, Dong, Y, Gustafsson, J A
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 1986
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386404/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3016728/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.16.5899
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