Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

The beta subunit of purified insulin receptor is phosphorylated on a serine residue by purified preparations of protein kinase C (ATP: protein phosphotransferase, EC 2.7.1.37). This phosphorylation is inhibited by antibodies to protein kinase C and stimulated by phospholipids, diacylglycerol, and Ca...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Bollag, G E, Roth, R A, Beaudoin, J, Mochly-Rosen, D, Koshland, D E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1986
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386387/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3526339/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.16.5822
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