Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets.

We have constructed synthetic peptides modeled on the sequences of (i) Arg-Gly-Asp, present in fibrinogen, fibronectin, and von Willebrand factor, and of (ii) the fibrinogen gamma chain (gamma 400-411) His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val. The concentration of each peptide that inhibits 5...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ruggeri, Z M, Houghten, R A, Russell, S R, Zimmerman, T S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386358/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3016716/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.15.5708
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